m nlrp3 inhibitor mcc950 (MedChemExpress)
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m nlrp3 inhibitor mcc950
M Nlrp3 Inhibitor Mcc950, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 648 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/m+nlrp3+inhibitor+mcc950/MCC950/pmc12900273-126-31-38
Average 99 stars, based on 648 article reviews
M Nlrp3 Inhibitor Mcc950, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 648 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/m+nlrp3+inhibitor+mcc950/MCC950/pmc12900273-126-31-38
Average 99 stars, based on 648 article reviews
m nlrp3 inhibitor mcc950 - by Bioz Stars,
2026-10
99/100 stars
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1) Product Images from "Hypothermic machine perfusion protects DCD graft liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via KLF2-NLRP3 signaling"
Article Title: Hypothermic machine perfusion protects DCD graft liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via KLF2-NLRP3 signaling
Journal: International Journal of Molecular Medicine
doi: 10.3892/ijmm.2026.5756
Figure Legend Snippet: KLF2 inhibits the NLRP3-mediated pyroptosis pathway during CS/Rep in ECs. (A) Heatmap and (B) volcano plot of differentially expressed genes between control and ov-KLF2 HUVECs after CS/Rep treatment. mRNA levels of (C) KLF2 and (D) NLRP3 in ov-control and ov-KLF2 group of HUVECs following CS/Rep treatment were quantified using reverse transcription-quantitative PCR. (E) Co-IP analysis of the interaction between KLF2 and NLRP3. (F) Microstructure of HUVECS. (G) Representative Western blot images for KLF2, NLRP3, GSDMD, Caspase-1 and IL-18 in CS/Rep HUVECs. Quantitative analysis of KLF2 (H), NLRP3 (I), GSDMD (J), Caspase-1 (K) and IL-18 (L) protein expression based on western blot results from HUVECS of ov-control and ov-KLF2 groups. Quantitative analysis of KLF2 (M), NLRP3 (N), GSDMD (O), Caspase-1 (P) and IL-18 (Q) protein expression based on western blot results from HUVECS of sh-control and sh-KLF2 groups. (n=3). * P<0.05, ** P<0.01, *** P<0.001. KLF2, Kruppel-like Factor 2; CS/Rep, cold storage/reperfusion; HUVEC, human umbilical vein endothelial cells; ov, overexpression; IP, immunoprecipitation; GSDMD, gasdermin D; sh, short hairpin;; FC, fold-change.
Techniques Used: Control, Reverse Transcription, Real-time Polymerase Chain Reaction, Co-Immunoprecipitation Assay, Western Blot, Expressing, Over Expression, Immunoprecipitation
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Incubation:Article Title: Hypothermic machine perfusion protects DCD graft liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via KLF2-NLRP3 signaling Article Snippet: The mixture was incubated at 37°C for 48 h. Stable cell lines were obtained following puromycin (cat. no. BL528A, Biosharp Life Sciences) selection for subsequent experiments. .. The incubation period between transfection and subsequent treatment was 72 h. To verify whether NLRP3 inhibition rescues the phenotypes resulting from KLF2 deficiency, sh-KLF2-transfected cells were treated (37°C) with 10 μ Transfection:Article Title: Hypothermic machine perfusion protects DCD graft liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via KLF2-NLRP3 signaling Article Snippet: The mixture was incubated at 37°C for 48 h. Stable cell lines were obtained following puromycin (cat. no. BL528A, Biosharp Life Sciences) selection for subsequent experiments. .. The incubation period between transfection and subsequent treatment was 72 h. To verify whether NLRP3 inhibition rescues the phenotypes resulting from KLF2 deficiency, sh-KLF2-transfected cells were treated (37°C) with 10 μ Inhibition:Article Title: Hypothermic machine perfusion protects DCD graft liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via KLF2-NLRP3 signaling Article Snippet: The mixture was incubated at 37°C for 48 h. Stable cell lines were obtained following puromycin (cat. no. BL528A, Biosharp Life Sciences) selection for subsequent experiments. .. The incubation period between transfection and subsequent treatment was 72 h. To verify whether NLRP3 inhibition rescues the phenotypes resulting from KLF2 deficiency, sh-KLF2-transfected cells were treated (37°C) with 10 μ |